Abstract: Based on the development history of earthquake macroscopic anomalies, this paper briefly describes the characteristics of pre- and post-earthquake macroscopic anomalies around the epicenter of the Pishan M_S5.1 earthquake in Hotan, Xinjiang Uygur Autonomous Region. Abnormal behavior of different animals, such as sheep, cattle, ducks, pigeons, pheasants and dogs, raised by rural farmers was described and analyzed. It is believed that the macroscopic anomalies of the earthquake have certain characteristics of short-term and imminent anomalies in time, are uneven in distribution, and are relatively close to the epicenter in general.