Abstract: This paper uses various channels to collect the data of earthquake disasters in 2022, and collates the global seismic activities and earthquake disasters in 2022. The change curves of global disaster earthquake frequency and casualties in recent 20 years and the distribution map of disaster earthquakes in 2022 were drawn. By summarizing the earthquake information and disaster conditions causing casualties, a detailed analysis of major earthquake disasters was made. The main characteristics of global earthquake disasters in 2022 were summarized, and major earthquake events in Afghanistan were listed. Compared with last year’s earthquake, the number of casualties caused by earthquake disasters in 2022 has decreased, and the disaster earthquakes are characterized by concentrated casualties and frequent secondary disasters. In view of the prominent causes of earthquake casualties, this paper puts forward corresponding earthquake disaster prevention measures and suggestions.