Abstract: Popular science work on earthquake prevention and disaster reduction should keep pace with the times, play a greater role in public opinion guidance, and take more responsibility in public opinion governance. This paper discusses that the popularization of science on earthquake prevention and disaster reduction plays an important role in guiding public opinion from two aspects. First, the hot spots of public opinion provide an opportunity for the popularization of science on earthquake prevention and disaster reduction. Second, the hot spots of public opinion provide content for the popularization of science on earthquake prevention and disaster reduction.Second, the hot spots of public opinion provide content for the popularization of science on earthquake prevention and disaster reduction. I put forward the public opinion guidance strategy of earthquake prevention and disaster reduction science popularization from three aspects. First, reasonably set the science popularization agenda and take the initiative to guide public opinion; Second, consciously guide public opinion by means of new media communication technology; The third is to play a good “combination boxing” to form the greatest resultant force for public opinion guidance. In the hot spots of public opinion, actively do a good job of popular science publicity on earthquake prevention and disaster reduction, innovate communication forms and methods, skillfully set the agenda, cover the whole time and space, and participate in the whole society, build a benign public opinion field for the exchange of information between the government, the media and the public, enhance the public's risk awareness and disaster prevention ability, and truly build a people's defense line for risk prevention and control.