Abstract: The collision between the Indian and the Eurasian plates is the most important geological event in the world since the Cenozoic. And the Tibetan Plateau has risen rapidly, becoming the world’s third pole and expanding outward continuously. There are development of active fault zones, complicated geological structure, strong seismicity and volcanic activity. The Tibetan Plateau and its surrounding areas as a natural experimental site for studying the dynamic mechanism of plateau uplift and deep structure deformation, are also an important focus in the fields of geosciences, geophysics and continental dynamics. Based on the academic report of WTGTP2020, this paper expounds some new progress in the study of deep structure and dynamics of the Tibetan Plateau. This seminar systematically discussed topics such as lithosphere structure, structure deformation mechanism, material migration dynamics pattern in the Tibetan Plateau. Based on the formation and evolution history of the Tibetan Plateau, the deep structure and magmatic metamorphic response, the shallow surface process and its impact on resources and climate are discussed. This organically links the interaction of different spheres such as deep geophysics, continental dynamics, surface processes and climate change.