Abstract: The core computer room of Hebei Earthquake Agency has businesses such as earthquake quick report and earthquake prediction. This paper analyzes the current situation of the old core computer room, and points out that the relocation of the computer room takes the minimization of business impact as the overall principle. Relocation implementation is completed through the steps of preparation and inspection of the new computer room, data backup and system detection, equipment sorting and inspection, operators’ optical cable fusion and link cutover, relocation and dust removal, testing and acceptance on equipment power. The summary and reflection on the problems arising from the relocation provide a material basis and strong support for the future operation of various businesses such as earthquake measurement, early warning and emergency of Hebei Earthquake Agency, and provide reference for the relocation of computer rooms of other Earthquake Agencies.