Abstract: Zhejiang Province is located in the southern part of the Yangtze River Delta, eastern part of China, which is an economically developed province and playing an important role in national economic development. However, its seismic fortification standard has been at a relatively low level, and the new generation of zoning map has a significant breakthrough adjustment to the seismic fortification standard of Zhejiang Province. Therefore, this paper mainly analyzes the changes of the fourth and fifth generation seismic zoning map, as well as the earthquake damage prevention problems. Finally, suggestions and countermeasures for the next step are put forward.