Abstract: In this paper, five series of large earthquakes that occurred from 1303 to 2005 in China are studied. The first series of large earthquakes to the fifth series of large earthquakes in order of east-center west-east region in China finished in 2005. Five series of large earthquakes were inactive from 2006 up to 2016. Five series of large earthquakes from the first series to the fifth was one rotation. The large earthquakes and the large earthquakes series are predicted by correlation between the series of larges earthquakes, so that the series of large earthquakes in the earthquakes prediction are profitable.