Abstract: Taking the static water level observation data of Fapa well in Dehong and the recorded co-seismic response events as the research object, the operation, tidal factor, observation accuracy and co-seismic response characteristics of the static water level observation data of Fapa well are systematically analyzed. The results show that the diurnal variation of the solid tide of Fapa static water level is clear, and the variation pattern shows obvious daily wave and semi-daily wave. The tidal response ability is strong, and the observation data accuracy is high. The well has strong response ability to large earthquakes. The static water level of Fapa well shows different co-seismic response patterns to different earthquakes, mainly in the form of oscillation. The variation range of the co-seismic response of the well water level is generally negatively correlated with the well-seismic distance and positively correlated with the magnitude. The co-seismic response time is positively correlated with the well-seismic distance. Finally, the mechanism of co-seismic response characteristics of water level is comprehensively analyzed, and the related mechanism is preliminarily discussed in combination with the specific situation of Fapa well.