Abstract: Using static water level observation data from Dehongfapa well and recorded co-seismic response events as the research objects, the operation, tidal factor, observation accuracy, and co-seismic response characteristics of the static water level observation data of Dehongfapa well were systematically analyzed. The results showed clear diurnal variations in the solid tide affecting the Dehongfapa well static water level, and the variation pattern showed obvious daily and semi-daily waves, the observational data were highly accurate and a strong tidal response ability was noted. The well exhibited a strong response to large earthquakes, and the static water level showed different co-seismic response patterns for different earthquakes, mainly in the form of oscillations. The variation range of the co-seismic response of the well water level was generally negatively correlated with the well-seismic distance and positively correlated with the magnitude, and the co-seismic response time was positively correlated with the well-seismic distance. Finally, the mechanism of the co-seismic response characteristics of the water level was comprehensively analyzed, and the related mechanism was preliminarily discussed in combination with the specific situation of Dehongfapa well.