Abstract: This paper focuses on the situation of earthquake organizational reforms in cities and counties in Anhui Province, with a specific analysis of the work status, characteristics, and problems of grassroots earthquake prevention and disaster reduction organizations in Ma’anshan City after the reform. Due to the request of new period, new circumstance, new mission, based on the important issues of the current earthquake prevention and combined with practical work, innovating ideas for earthquake prevention and disaster reduction work, five targeted strategies are proposed. Improve system construction and enhance collaborative and linkage capabilities; Strengthen the legal foundation and improve comprehensive law enforcement capabilities; Increase security efforts and improve grassroots basic capabilities; Promote intelligent construction and enhance science and technology innovation capabilities; Cultivate earthquake culture and enhance earthquake prevention and disaster reduction publicity capabilities. The results have certain practical guiding significance for further strengthening the earthquake grassroots work under the new emergency management system.