Abstract: In this paper, the characteristics of time, space, strong and activity frequency, b value, strain energy release of moderate earthquakes in southern Jiangxi and neighboring areas (23.66°N～27.20°N, 113.50°N～118.84°E) areanalyzed. The results show that, the region has the background of moderate and strong seismicity, and modern small earthquakes are distributed in dense belts. The main aftershock type and swarm type are the main earthquake sequences above moderate strength. Since 1971, seismic activity has continued to be active, with earthquakes of M_L≥4.0 exhibiting obvious clustering property, mainly manifested by the spatial and temporal concentration of seismic activity; The seismicity of M_L≥3.5 earthquakes has periodic characteristics, including the high active period, the quiet period and the occurrence of destructive earthquake events; When the b value is always lower than the annual average value, the moderate and strong earthquakes are active; The rate of strain energy release curve shows an accelerating trend before moderate earthquakes are active. The results of this study provide some important reference information for predicting the time, space and intensity of earthquakes in this region, which helps to closely observe the seismic activity in the region.