Abstract: As the institutional reform of China’s seismic system and the “14th Five-Year” plan continue to advance, the layout of seismic scientific instruments in the Earthquake Agency of Xinjiang Uygur Autonomous Region has become more dense, digitalized and modernized. As a grassroots central station, the number of instruments that need to be maintained is increasing, and the technical requirements for instrument management and maintenance and the pressure of operation and maintenance are increasing. The geophysical station network, as a frontline position for observing and studying crustal motion and deformation processes, identifying strong earthquake breeding stages and exploring strong earthquake prediction, has a direct impact on the quality of data output and thus on data analysis results and earthquake breeding identification. Therefore, in this paper, we propose some suggestions to improve the efficiency of instrument operation and maintenance for the current situation and problems of the geophysical station network management and maintenance between the operation and maintenance office of Xinjiang geophysical observation center and the central station through literature analysis and interview method.