Abstract: Shanghai Earthquake Agency has made efforts to explore characteristic brands of science popularization of earthquake prevention and disaster reduction, and has formed a number of themed activity columns, such as “Knowledge Competition of Earthquake Prevention and Disaster Reduction for Middle School Students” “Zhen Zhen YouCi” “Yan Gui Zhen Zhuan” , which had achieved certain popularity and achievements. However, these activities are independent and scattered from each other, and there are still some problems in the construction and design of related promotional cultural and creative products such as limited high-quality products and insufficient innovation. The purpose of this paper is to sort out and summarize the current popular science propaganda works of Shanghai Earthquake Agency, extend the vision to the seismic system, Shanghai and even the country’s multi field cultural and creative productsof science popularization, sum up experience, learn from each other’s strengths. In the context of digital informatization and the “Internet +” model, we should actively think and rely on the integration media platform. We should try to explore the direction of cultural and creative product of science popularization for earthquake prevention and disaster reduction that can represent the characteristics of the administration, drive brand effect, and be easy to promote. We should promote the diversification and enrichment of publicity forms of earthquake prevention and disaster reduction in Shanghai, and reach a new level in communication channels and social audience coverage.