Abstract: Based on the processing and analysis of the fixed-point horizontal deformation data across the fault in the middle and southern part of the Tan-Lu fault zone in recent 20 years, this paper preliminarily analyzes the vertical deformation characteristics of the middle and southern section of the Tan-Lu fault. The research shows that the overall activity level of the middle and southern part of the Tan-Lu fault zone is not high, and the average combining rate is 0.19 mm/a. However, it has obvious characteristics of time-sharing activities: from 2000 to 2010, the activity in Huaibai-Suqian section was large, while the activity in Xinyi-Linyi section was relatively small. There was a relatively closed section between Suqian and Xinyi; The overall activity rate has decreased from 2011 to 2019, but the activity rate of Anqiu station has increased significantly compared with that of 2000 to 2011. There is a certain correspondence between the activitycharacteristics of the fault zone and the seismicity of the region in the past 20 years.