Abstract: Based on the earthquake disaster data collected by various routes, this paper sorts out the global seismic activity and disasters in 2021. Variation curves of global disaster earthquake frequency with casualties in this century at the beginning twenty years and distribution map of hazard earthquakes in 2021 were plotted. And the earthquake information and disaster situation of earthquakes with casualties were described. Correspondingly, the major earthquake disasters were analyzed in detail, and the main characteristics of global earthquake disasters in 2021 were summarized. Compared with the previous earthquake, it is found that the seismicity is strong in 2021, especially to the occurrence rate of earthquakes with magnitude 8 and above. In 2021, the number of casualties caused by earthquake increased, and disaster earthquakes were characterized by high frequency, concentrated casualties, and frequent secondary disasters. According to the situation of high earthquake frequency and prominent causes of casualties, this paper puts forward corresponding measures and suggestions for earthquake disaster prevention, which emphasizes the importance of earthquake prevention work for the future.