Abstract: Schools are important places to carry out earthquake disaster education. Earthquake prevention and disaster reduction publicity and education in colleges and universities can help improve the results of earthquake safety education in primary and secondary schools. It is important to strengthen the awareness and skills of college students in earthquake prevention and disaster reduction, so that they can change their role to provide services to the society, and take the initiative to undertake the publicity and popularization of earthquake disasters, which is conducive to improving the ability of earthquake prevention and disaster preparedness of the whole people. In view of the problems found in the practice of popular science popularization, this paper compares the differences between universities and other academic sections of earthquake popular science popularization through questionnaire survey, analyzes the reasons and summarizes the experience, and puts forward the ways to strengthen the publicity and education of earthquake prevention and disaster reduction in universities. The analysis points out that the publicity and education of earthquake prevention and disaster reduction for college students is a continuous and dynamic project, and colleges and universities need to vigorously carry out earthquake safety education in many aspects such as concept, knowledge, skills and responsibilities, and at the same time need to rely on the strength and resources of relevant departments to improve the publicity and education effect.