Abstract: Based on the development history of earthquake macroscopic anomalies, this paper briefly describes the characteristics of earthquake macroscopic anomalies, and describes the abnormal behavior of different animals, such as sheep, cattle, ducks, pigeons, pheasants and dogs, raised by rural farmers around the site of the Pishan Ms5.1 earthquake in Hotan, Xinjiang Uygur Autonomous Region, and makes statistics and analysis. It is believed that the macroscopic anomalies of the earthquake have certain characteristics of short-term and imminent anomalies in time, and are uneven in distribution, and are generally concentrated in villages relatively close to the epicenter.