Abstract: China is a country prone to earthquakes, which have caused serious losses to people's lives and property. In the current situation where earthquake monitoring and prediction are not yet mature, the public's demand for earthquake information is increasing. Therefore, doing a good job in earthquake prevention and disaster reduction science popularization is an important task at present. It is necessary to design a specialized earthquake prevention and disaster reduction science popularization information dissemination system to better serve the public's popularization of earthquake knowledge, provide rich content, diverse forms, and extensive systems, and meet the public's needs for earthquake knowledge. This paper in WAMP integrated development environment, uses MySQL database to collect the information of earthquake prevention and disaster reduction such as articles, pictures, video and audio, and uses PHP language to design and implement a set of popular science information publishing system of earthquake prevention and disaster reduction based on B/S structure. The system reasonably classifies the information and has the functions of search, query and message interaction. It provides a standardized, convenient and effective channel for the public to accurately obtain the knowledge of earthquake prevention and disaster reduction.