Abstract: The construction of Dali-Lincang railway has caused serious interference to the seismic observation environment of Yunxian Seismic Station. In order to support the construction of major projects and properly handle the relationship between railway construction and environmental protection of seismic observation, Yunnan Earthquake Agency determined to solve the problem of observation environmental protection of Yunxian Seismic Station based on the principle of “keep the the main body of Yunxian Seismic Station and move the most affected measurement items to a suitable site”. In the process of relocation, the seismic department attached great importance to it, established a coordination and promotion mechanism, and made scientific decisions according to law; The cadres and staff of the seismic station intervene actively, cooperate closely and act actively; Geological conditions, ambient noise, human environment and other factors were fully considered in the site selection. At present, the relocated observation station has been basically completed. The experience and lessons obtained can provide reference for the observation environmental protection of seismic stations.